15+ YEARS OF SCIENCE BEHIND SIPORE®
Science That Reduces the Impact of Modern Meals
Developed in Sweden through more than 15 years of research, SiPore® is a patented technology designed to work locally in the gut and slow the breakdown of carbohydrates and fats.
15+
Years of research
6
Clinical trials
9
Peer-reviewed publications
318
Participants in SHINE
Published in eClinicalMedicine
Part of The Lancet Discovery Science portfolio
THE SCIENCE STARTS WITH THE MEAL
Modern Food Is Fast. Your Biology Isn't.
Modern meals can deliver carbohydrates and fats very quickly.
When digestion happens fast, the body can experience sharper post-meal rises and dips. For many people, that can mean less stable energy, greater hunger and a stronger urge to snack.
SiPore® was developed around a different idea: reduce the impact of the meal itself — where digestion begins.
Less impact per meal. Stability over time.
THE IDEA BEHIND SIPORE®
A Different Question About Metabolic Health.
More than 15 years ago, Professor Tore Bengtsson and his team began exploring a different approach to metabolic health. Instead of focusing only on what happens after nutrients enter the bloodstream, they looked earlier in the process, at digestion itself.
Their question was simple:
Could we reduce the impact of modern meals by changing how carbohydrates and fats are broken down in the gut?
That research led to SiPore®, a patented technology designed to work locally during digestion.
HOW SIPORE® WORKS
Works Locally In The Gut. From The First Meal.
SiPore® begins working during digestion of the first meal you take it with. There is no loading period required for its local mode of action.
1
Take it with your meal
SiPore® is taken just before or with the first bites of food. It works locally in the gastrointestinal tract, where digestion happens, and does not enter the bloodstream.
2
Entraps digestive enzymes
SiPore® contains precisely engineered pores that entrap a portion of digestive enzymes such as amylase and lipase. These enzymes are responsible for breaking down carbohydrates and fats from food.
3
Slows the breakdown of carbohydrates and fats
With fewer digestive enzymes available to act on the meal, carbohydrates and fats are broken down more gradually. This supports a steadier post-meal response.
LOCAL, NOT SYSTEMIC
SiPore® works in the gut and does not enter the bloodstream.
THE LARGEST CLINICAL TRIAL OF SIPORE® TO DATE
The SHINE Trial
SHINE was a randomized, double-blind, placebo-controlled clinical trial in adults with overweight or obesity and prediabetes or early type 2 diabetes. Results were published in eClinicalMedicine, part of The Lancet Discovery Science portfolio.
READ THE SHINE STUDY
318
Participants
12 weeks
Study duration
27
Clinical centers
Randomized · Double-blind
Placebo-controlled
GLYCEMIC CONTROL
HbA1c
Helped maintain
beta-cell function
BODY COMPOSITION
Body weight
Body fat
Waist circumference
Lean mass preserved
CARDIOMETABOLIC HEALTH
LDL cholesterol
Total cholesterol
SAFETY & TOLERABILITY
Generally well tolerated
No serious device-related adverse events reported
BUILT THROUGH YEARS OF CLINICAL RESEARCH
A Complete Research Program
From first-in-human safety to the large randomized SHINE trial, each study was designed to answer a different question about how SiPore® works and what it can do.
1
First-in-Human
N=20
Can it be used safely in humans?
Established safety and tolerability in humans and provided early evidence supporting SiPore®’s mechanism of action.
2
STAR
N=43
Can it improve longer-term metabolic health?
Significantly reduced HbA1c in people with prediabetes or newly diagnosed type 2 diabetes.
3
Postprandial
N=20
Does it affect the response to a single meal?
A single 3 g dose significantly reduced post-meal blood glucose versus placebo in a starch challenge.
4
CGM Study 1
N=20
What happens to glucose stability across the day?
Increased Time in Range and reduced hypoglycemic events versus placebo.
5
CGM Study 2
N=29
What happens at the Carb Fence dose?
Reduced daytime glucose variability and upper-range glucose exposure.
6
SHINE
N=318
Does it hold up in a large randomized trial?
Confirmed broader metabolic benefits and safety in the largest clinical study of SiPore® to date.
REAL-WORLD EVIDENCE WITH CARB FENCE™
What Happens In Real Life?
In a 4-week U.S. real-world evidence study, adults with overweight or obesity used Carb Fence with their meals.
19%
↓ Hunger
30%
↓ Urge to snack
25%
↓ Sugar cravings
24%
↓ Post-meal fatigue
62%
of participants experienced weight loss over four weeks
4.2 lbs
average weight reduction among responders
95% Daily compliance
Generally well tolerated
No serious adverse events
Source: U.S. Real-World Evidence Study, 2025. Study enrolled N=80.
SAFETY BY DESIGN
Designed To Work In The Gut. Not Throughout The Body.
Gut-local
Works where digestion happens
Non-systemic
Does not enter the bloodstream
Studied at up to 9 g/day
Evaluated in human clinical research
Generally well tolerated
Supported across multiple studies
In the SHINE clinical trial, no serious adverse device effects were reported.
TWO PRODUCTS, ONE TECHNOLOGY
Designed For Different Needs.
Medical food for targeted dietary management. Our highest-dose SiPore® format.
Dietary supplement for everyday metabolic support.
BORN FROM SWEDISH RESEARCH
SiPore® was developed by Professor Tore Bengtsson and his team at Stockholm University. Our mission is to reduce the negative impact of modern food and help more people live healthier, more stable lives.
